Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxl2  forkhead box L2   (Synonyms: Pfrk)
Results	Reference
1	J:326017 Ademi H, Djari C, Mayere C, Neirijnck Y, Sararols P, Rands CM, Stevant I, Conne B, Nef S, Deciphering the origins and fates of steroidogenic lineages in the mouse testis. Cell Rep. 2022 Jun 14;39(11):110935
1	J:250302 Bagheri-Fam S, Bird AD, Zhao L, Ryan JM, Yong M, Wilhelm D, Koopman P, Eswarakumar VP, Harley VR, Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2. Endocrinology. 2017 Nov 01;158(11):3832-3843
1	J:285178 Bagheri-Fam S, Chen H, Wilson S, Ayers K, Hughes J, Sloan-Bena F, Calvel P, Robevska G, Puisac B, Kusz-Zamelczyk K, Gimelli S, Spik A, Jaruzelska J, Warenik-Szymankiewicz A, Faradz S, Nef S, Pie J, Thomas P, Sinclair A, Wilhelm D, The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice. PLoS One. 2020;15(1):e0227411
1	J:335514 Bird AD, Frost ER, Bagheri-Fam S, Croft BM, Ryan JM, Zhao L, Koopman P, Harley VR, Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary. Endocrinology. 2023 Mar 13;164(5)
1*	J:271281 Bowles J, Feng CW, Ineson J, Miles K, Spiller CM, Harley VR, Sinclair AH, Koopman P, Retinoic Acid Antagonizes Testis Development in Mice. Cell Rep. 2018 Jul 31;24(5):1330-1341
1	J:309359 Brinkmeier ML, Bando H, Camarano AC, Fujio S, Yoshimoto K, de Souza FS, Camper SA, Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. J Clin Invest. 2020 Aug 3;130(8):4501-4515
1*	J:189715 Chen H, Palmer JS, Thiagarajan RD, Dinger ME, Lesieur E, Chiu H, Schulz A, Spiller C, Grimmond SM, Little MH, Koopman P, Wilhelm D, Identification of novel markers of mouse fetal ovary development. PLoS One. 2012;7(7):e41683
1	J:290670 Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A, Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13680-13688
1	J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
1	J:276930 Garcia-Moreno SA, Lin YT, Futtner CR, Salamone IM, Capel B, Maatouk DM, CBX2 is required to stabilize the testis pathway by repressing Wnt signaling. PLoS Genet. 2019 May;15(5):e1007895
1	J:263354 Gonen N, Futtner CR, Wood S, Garcia-Moreno SA, Salamone IM, Samson SC, Sekido R, Poulat F, Maatouk DM, Lovell-Badge R, Sex reversal following deletion of a single distal enhancer of Sox9. Science. 2018 Jun 29;360(6396):1469-1473
1*	J:238708 Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R, Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 2017 Jan;13(1):e1006520
1*	J:231673 Gustin SE, Hogg K, Stringer JM, Rastetter RH, Pelosi E, Miles DC, Sinclair AH, Wilhelm D, Western PS, WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary. Dev Biol. 2016 Apr 15;412(2):250-60
1	J:310001 Ikeda Y, Tagami A, Komada M, Takahashi M, Expression of Kisspeptin in Gonadotrope Precursors in the Mouse Pituitary during Embryonic and Postnatal Development and in Adulthood. Neuroendocrinology. 2017;105(4):357-371
1	J:303384 Ikeda Y, Tagami A, Maekawa M, Nagai A, The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep. 2021 Feb 24;11(1):4486
1	J:188056 Jameson SA, Lin YT, Capel B, Testis development requires the repression of Wnt4 by Fgf signaling. Dev Biol. 2012 Oct 1;370(1):24-32
1*	J:168597 Kashimada K, Pelosi E, Chen H, Schlessinger D, Wilhelm D, Koopman P, FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology. 2011 Jan;152(1):272-80
1*	J:297658 Kulibin AY, Malolina EA, Formation of the rete testis during mouse embryonic development. Dev Dyn. 2020 Aug 27;
1	J:200895 Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M, Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science. 2013 Sep 6;341(6150):1106-9
1	J:246359 Kuroki S, Okashita N, Baba S, Maeda R, Miyawaki S, Yano M, Yamaguchi M, Kitano S, Miyachi H, Itoh A, Yoshida M, Tachibana M, Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance. PLoS Genet. 2017 Sep;13(9):e1007034
1	J:173657 Lavery R, Lardenois A, Ranc-Jianmotamedi F, Pauper E, Gregoire EP, Vigier C, Moreilhon C, Primig M, Chaboissier MC, XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. Dev Biol. 2011 Jun 1;354(1):111-22
1*	J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
1	J:317364 Li SY, Gu X, Heinrich A, Hurley EG, Capel B, DeFalco T, Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis. Biol Reprod. 2021 Oct 11;105(4):958-975
1	J:246806 Li Y, Zhang L, Hu Y, Chen M, Han F, Qin Y, Chen M, Cui X, Duo S, Tang F, Gao F, beta-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. J Biol Chem. 2017 Oct 27;292(43):17577-17586
1	J:138861 Maatouk DM, DiNapoli L, Alvers A, Parker KL, Taketo MM, Capel B, Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal. Hum Mol Genet. 2008 Oct 1;17(19):2949-55
1	J:192186 Maatouk DM, Mork L, Hinson A, Kobayashi A, McMahon AP, Capel B, Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One. 2012;7(10):e47238
1	J:143586 Manuylov NL, Smagulova FO, Leach L, Tevosian SG, Ovarian development in mice requires the GATA4-FOG2 transcription complex. Development. 2008 Nov;135(22):3731-43
1	J:239654 Marongiu M, Marcia L, Pelosi E, Lovicu M, Deiana M, Zhang Y, Puddu A, Loi A, Uda M, Forabosco A, Schlessinger D, Crisponi L, FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice. BMC Dev Biol. 2015 Jul 02;15:27
1	J:326550 Mayere C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, Bellido-Carreras N, Sararols P, Reeves R, Greenaway S, Simon M, Siggers P, Condrea D, Kuhne F, Gantar I, Tang F, Stevant I, Batti L, Ghyselinck NB, Wilhelm D, Greenfield A, Capel B, Chaboissier MC, Nef S, Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad. Sci Adv. 2022 May 27;8(21):eabm0972
1	J:334329 Ogawa Y, Terao M, Tsuji-Hosokawa A, Tsuchiya I, Hasegawa M, Takada S, SOX9 and SRY binding sites on mouse mXYSRa/Enh13 enhancer redundantly regulate Sox9 expression to varying degrees. Hum Mol Genet. 2023 Jan 1;32(1):55-64
1*	J:284860 Okashita N, Kuroki S, Maeda R, Tachibana M, TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression. Sci Rep. 2019 Sep 17;9(1):13462
1	J:338020 Okashita N, Maeda R, Tachibana M, CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2221499120
1*	J:87109 Pannetier M, Servel N, Cocquet J, Besnard N, Cotinot C, Pailhoux E, Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals. Cytogenet Genome Res. 2003;101(3-4):199-205
1	J:197599 Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S, Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
1	J:155544 Polanco JC, Wilhelm D, Davidson TL, Knight D, Koopman P, Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development. Hum Mol Genet. 2010 Feb 1;19(3):506-16
1	J:202060 Rakoczy J, Fernandez-Valverde SL, Glazov EA, Wainwright EN, Sato T, Takada S, Combes AN, Korbie DJ, Miller D, Grimmond SM, Little MH, Asahara H, Mattick JS, Taft RJ, Wilhelm D, MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod. 2013 Jun;88(6):143
1	J:216158 Rastetter RH, Bernard P, Palmer JS, Chassot AA, Chen H, Western PS, Ramsay RG, Chaboissier MC, Wilhelm D, Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014 Oct 15;394(2):242-52
1	J:327192 Rossitto M, Dejardin S, Rands CM, Le Gras S, Migale R, Rafiee MR, Neirijnck Y, Pruvost A, Nguyen AL, Bossis G, Cammas F, Le Gallic L, Wilhelm D, Lovell-Badge R, Boizet-Bonhoure B, Nef S, Poulat F, TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway. Nat Commun. 2022 Jul 29;13(1):4412
1	J:340721 Schindler M, Osterwalder M, Harabula I, Wittler L, Tzika AC, Dechmann DKN, Vingron M, Visel A, Haas SA, Real FM, Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes. Development. 2023 Sep 1;150(17)
1*	J:336188 Terao M, Ogawa Y, Takada S, Kajitani R, Okuno M, Mochimaru Y, Matsuoka K, Itoh T, Toyoda A, Kono T, Jogahara T, Mizushima S, Kuroiwa A, Turnover of mammal sex chromosomes in the Sry-deficient Amami spiny rat is due to male-specific upregulation of Sox9. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2211574119
1	J:324297 Thomson E, Zhao L, Chen YS, Longmuss E, Ng ET, Sreenivasan R, Croft B, Song X, Sinclair A, Weiss M, Koopman P, Pelosi E, Generation and mutational analysis of a transgenic mouse model of human SRY. Hum Mutat. 2022 Mar;43(3):362-379
1*	J:278064 Tsuji-Hosokawa A, Kashimada K, Kato T, Ogawa Y, Nomura R, Takasawa K, Lavery R, Coschiera A, Schlessinger D, Harley VR, Takada S, Morio T, Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Sci Rep. 2018 Sep 5;8(1):13263
1	J:203711 Wainwright EN, Jorgensen JS, Kim Y, Truong V, Bagheri-Fam S, Davidson T, Svingen T, Fernandez-Valverde SL, McClelland KS, Taft RJ, Harley VR, Koopman P, Wilhelm D, SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation. Biol Reprod. 2013 Aug;89(2):34
1*	J:216502 Wainwright EN, Svingen T, Ng ET, Wicking C, Koopman P, Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice. Dev Biol. 2014 Nov 15;395(2):342-54
1*	J:149243 Wilhelm D, Washburn LL, Truong V, Fellous M, Eicher EM, Koopman P, Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev. 2009 May-Jun;126(5-6):324-36
1	J:339060 Xu W, Yang Y, Yu Y, Wen C, Zhao S, Cao L, Zhao S, Qin Y, Chen ZJ, FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells. BMC Biol. 2023 Aug 15;21(1):174
1	J:213934 Zhao L, Ng ET, Davidson TL, Longmuss E, Urschitz J, Elston M, Moisyadi S, Bowles J, Koopman P, Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11768-73
1	J:338076 Zhao L, Thomson E, Ng ET, Longmuss E, Svingen T, Bagheri-Fam S, Quinn A, Harley VR, Harrison LC, Pelosi E, Koopman P, Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice. Sex Dev. 2022;16(4):270-282
1	J:333722 Zhao S, Huang C, Yang Y, Xu W, Yu Y, Wen C, Cao L, Gao F, Qin Y, Chen ZJ, Guo T, Zhao S, DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development. J Biol Chem. 2023 Jan 13;299(3):102905